化工機械設備網
資料下載
細胞膜蛋白Derlin抗體用途
閱讀：196 發布時間：2021-11-12| 提 供 商 | 上海古朵生物科技有限公司 | 資料大小 | 13.4KB |
|---|---|---|---|
| 資料圖片 | 下載次數 | 9次 | |
| 資料類型 | WORD 文檔 | 瀏覽次數 | 196次 |
| 免費下載 | 點擊下載 |
中文名稱 細胞膜蛋白Derlin抗體
英文名稱 DERLIN-1
別 名 Derlin1; Derlin1; Derlin 1; DER1; DER-1; DER 1; DERL1_HUMAN.
研究領域 細胞生物 細胞膜蛋白
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
產品應用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
細胞定位 細胞漿 細胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DERLIN-1:111-220/251
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 Degradation in endoplasmic reticulum proteins, also designated Derlins or DERtrins, are crucial for the degradation of misfolded endoplasmic reticulum (ER) luminal proteins. Derlin proteins are multi-pass membrane proteins localizing to the ER. Derlins are involved in transferring misfolded proteins from the ER to the cytosol, where the misfolded proteins are destroyed in an ubiquitin-dependent manner by the proteasome. In the case of cytomegalovirus infection, Derlin-1, as opposed to Derlins-2 and -3, is involved in the export of MHC class I heavy chains from the ER via its interaction with the viral protein US11. Derlins may also be important for cell proliferation.